Journal of Chemistry and Nutritional Biochemistry

In silico evaluation of natural bioactive compounds as Mycobacterium leprae enoyl acyl carrier protein reductase inhibitors

Haitham Al-Madhagi — Sun, 07 Aug 2022 00:00:00 +0000

Background and Objectives:

The present study was designed to assess the antileprotic effectiveness of some bioactive natural compounds towards enoyl acyl carrier protein reductase inhibition. Leprosy still constitutes a global pandemic in spite of long years of discovery. The current therapy option is multi-drug treatment using a combination of Dapsone, Rifampicin and Clofazimine. However, mycobacterium leprae counteracted by mutating the drug targets which necessitates the search for novel targets. One such target is enoyl acyl carrier protein reductase that mediates the fatty acid biosynthesis.

Materials and Methods:

Multiple (14) ligands of natural origin were drawn from PubChem database and their ADMET parameters were preicted using ADMETLab 2.0 webserver. After, the ligands were docked against the enzyme (PDB ID: 2NTV) at its active site using iGEMDOCK software.

Results:

ADMET parameters of the tested ligands proven to be accepted by Lipinski's rule of five except for two ligands. Furthermore, molecular docking results revealed that all of the tested compounds showed better binding energy than the reference drug Dapsone. The best of which was silymarin.

Conclusion:

The tested natural ligands have the capability to control M.leprae.

Determination of Toxic Concentrations of Heavy Metals in Selected Samples of Tobacco Products

Sun, 07 Aug 2022 00:00:00 +0000

The foremast threats to human health from heavy metals are related with use tobacco when inserted in the human body by smoking ( shisha and cigarette ) or chewable like shammah which is harm of health. The tobacco species have been collected from different places, natural or included in the installation of some of the species sold in the markets. The samples were analyzed by wet digestion method and standardized. International protocols were followed for the preparation of material and analysis of heavy metals contents and analyzed by Inductively coupled plasma spectrometer Model-Varian720 ES in center Laboratory in Meteorology, Environment and Arid Land Agriculture, and Center of Excellence in Environmental Studies, King Abdulaziz University (KAU). Results obtained using ICP-OES technique for determination of heavy metals in Tobacco products. Through this study the results were shown the heavy metals which found in tobacco samples is clearly. the objective of the study showing the concentrative the heavy metals in tobacco and compared with levels of heavy metals allowing in the World Health Organization (WHO ). What the results indicate is the seriousness of the presence of heavy metals, which cause serious diseases such as cancer and failure in most organs. The use of tobacco should be abandoned.

A REVIEW ON PHYTOCHEMICHAL AND PHARMACHOLOGICAL PROPORTIES OF COFFEE ARABICA PLANT

Yousef Abdulwahab, Ahyar ahmad, Isra Wahid, Paulina Tapa — Sun, 07 Aug 2022 00:00:00 +0000

Coffee, which is a member of the Rubiaceae family and is one of the most exporters and importers and consumed drinks globally, is also used as food and medicine. It contains a lot of terpenes, amino acids, sugars, fatty acids, lipids, alkaloids, saponins, glycosides, flavonoids, and other compounds that have antioxidant, anti-inflammatory, anticancer, antidiabetic, live-protective, and neuroprotective activities. In order to provide a data basis for potential opportunities of pharmaceutical development, we collected data on the advancement of phytoconstituents and bioactivities of coffee arabica.

PROXIMATE ANALYSIS OF THREE VARIETIES OF KOLA NUT SELECTED FROM ALAMISI MARKET IKIRUN, OSUN STATE NIGERIA.

ADEKUNLE OLAOYE — Sun, 07 Aug 2022 00:00:00 +0000

Three (3) varieties of Cola, a tropical African crop of the family Sterculiacea, were gotten from Ikirun, State of Osun Nigeria, conventional method was used to cured it by wrapping it in clean leaves of banana to decrease the quantity of moisture lost and after that set aside for fourteen days in the laboratory before used. Association of Official Analytical Chemists (AOAC) 1984 methods was used to carry out proximate analysis of the species. The results obtained showed that Cola nitida had (60.80%), moisture, (2.94%) ash, (7.91%) crude protein, and (2.70%) caffeine. Cola accuminata had (56.30%) moisture, (3.04%) ash, (8.68%), crude protein and (2.75%) caffeine, while Garcinia Kola had (51.30%) moisture, (2.95%) ash, (8.90%) crude protein and (2.96%) caffeine.

Stem Cells Overview-Mini-Review

Hassan Alzahrani, Nawaf Almuntashiri, Rahma Kofiya — Sun, 07 Aug 2022 00:00:00 +0000

Stem cells are unique and highly powerful cells, which have immense potential for treating various conditions. There are different types of stem cells based on the sources they are derived from and also based on their ability to differentiate into other types of cells. The detailed study of stem cells is important for scientists to understand how the cells grow and differentiate, and how the human body works on a cellular level. In addition to the research interest in stem cells, the clinical applications of stem cells are increasing constantly. Stem cells can be induced to change into new cells of specific tissues or organs, which can then be used for treating diseases. There are already a few established stem cell therapies, and many more in clinical trials.